Skip to main content

SUDAFED PE® Day + Night Sinus Congestion Relief Decongestant Tablets*

These maximum strength decongestant tablets provide powerful relief of sinus and nasal congestion and sinus pressure relief, during both day and night. Each tablet contains 10 mg phenylephrine HCl decongestant, and the nighttime tablets contain 25 mg diphenhydramine HCl antihistamine.

*On November 8, 2024 the U.S. Food & Drug Administration (FDA) issued a proposed order to remove oral phenylephrine (PE) from the OTC monograph. The FDA proposed order is not related to safety.

Product Details

SUDAFED PE® Day & Night Congestion Relief Tablets provide maximum strength relief of multiple symptoms, including sinus congestion & pressure, nasal congestion, and runny nose. This multi-pack contains both daytime and nighttime decongestant tablets to help relieve symptoms all day and night. The day and nighttime tablets both contain 10 mg of phenylephrine HCl nasal decongestant to help relieve sinus congestion and pressure, and nasal congestion caused by the common cold, flu, or allergies. The nighttime decongestant tablets also contain 25 mg diphenhydramine HCl antihistamine to improve sleep at night by reducing sneezing, runny nose, itchy, watery eyes and itchy throat or nose.

From the #1 pharmacist recommended brand among oral OTC decongestants, this congestion relief medicine is suitable for adults and children ages 12+.

SUDAFED PE® Sinus Congestion Daytime

  • Temporarily relieves sinus congestion and pressure

  • Temporarily relieves nasal congestion due to the common cold, hay fever or other upper respiratory allergies

SUDAFED PE® Sinus Congestion Nighttime

In addition to the above, the nighttime tablets temporarily relieve these symptoms due to hay fever or other upper respiratory allergies:

  • Runny nose

  • Sneezing

  • Itchy, watery eyes

  • Itching of the nose or throat

Daytime Active Ingredients:

  • Phenylephrine HCl 10 mg - Nasal decongestant

Daytime Inactive Ingredients:

Carnauba wax, D&C yellow no. 10 aluminum lake, FD&C red no. 40 aluminum lake, FD&C yellow no. 6 aluminum lake, magnesium stearate, microcrystalline cellulose, modified starch, polyethylene glycol, polyvinyl alcohol, powdered cellulose, pregelatinized starch, sodium starch glycolate, talc, titanium dioxide

Nighttime Active Ingredients:

  • Diphenhydramine HCl 25 mg - Antihistamine

  • Phenylephrine HCl 10 mg - Nasal decongestant

Nighttime Inactive Ingredients:

Carnauba wax, FD&C blue no. 1 aluminum lake, magnesium stearate, microcrystalline cellulose, modified starch, polyethylene glycol, polyvinyl alcohol, powdered cellulose, pregelatinized starch, sodium starch glycolate, talc, titanium dioxide

Do not take the day and night tablets at the same time.

Do not take more than a total of 6 tablets in a 24-hour period.

Take only as directed.

Important: Read all product information before using. Keep box for important information.

Adults and children 12 years and over

  • Take 1 tablet every 4 hours

  • Do not take more than 6 tablets in 24 hours

Children under 12 years

  • Ask a doctor

SUDAFED PE® Sinus Congestion Daytime:

Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

Ask a doctor before use if you have

  • heart disease

  • high blood pressure

  • thyroid disease

  • diabetes

  • trouble urinating due to an enlarged prostate gland

When using this product do not exceed recommended dose

Stop use and ask a doctor if

  • nervousness, dizziness, or sleeplessness occur

  • symptoms do not improve within 7 days or occur with a fever

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

SUDAFED PE® Sinus Congestion Nighttime:

Do not use

  • to make a child sleepy

  • with any other product containing diphenhydramine, even one used on skin

  • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

Ask a doctor before use if you have

  • heart disease

  • high blood pressure

  • thyroid disease

  • diabetes

  • trouble urinating due to an enlarged prostate gland

  • a breathing problem such as emphysema or chronic bronchitis

  • glaucoma

Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers

When using this product

  • do not exceed recommended dose

  • marked drowsiness may occur

  • avoid alcoholic drinks

  • alcohol, sedatives, and tranquilizers may increase drowsiness

  • be careful when driving a motor vehicle or operating machinery

  • excitability may occur, especially in children

Stop use and ask a doctor if

  • nervousness, dizziness, or sleeplessness occur

  • symptoms do not improve within 7 days or occur with a fever

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

  • Store between 20-25°C (68-77°F)

Questions or comments?

Call 1-888-217-2117 (toll-free) or 215-273-8755 (collect)

Reviews