Skip to main content
Dosing Guide
Sudafed Logo
  • By Concern
    • Head Congestion
    • Sinus Congestion
    • Nasal Dryness
    By Category
    • Adult Products
    • Children's Products
    • All Products
    By Form
    • Saline + Nasal Sprays
    • Tablets + Caplets
    • Liquid
    Sudafed_OM_Sinus_Severe_No_Drip_Nasal_Spray_Card
    SUDAFED® Sinus Severe No Drip Nasal Spray
    SHOP NOW
  • Compare SUDAFED®
  • All Articles
    What Is Pseudoephedrine?
    Sinus Congestion vs. Head Congestion
    Head Congestion: Causes and Symptoms
    Sinus Pressure and Pain
    Can Allergies Cause Sinus Pressure?
  • FAQs
Search
SUDAFED® Sinus Congestion + Cold Severe Day/Night Tablets
SUDAFED®  2-IN-1 MAX STRENGTH
FSA/HSA Eligible
Sudafed #1 Pharmacist Recommended - Sinus care expert for over 60 years
FOR MAXIMUM STRENGTH RELIEF ASK FOR SUDAFED® AT THE PHARMACY COUNTER
Drug Facts
SUDAFED® Sinus Congestion + Cold Severe Day/Night Tablets
New
SUDAFED®  2-IN-1 MAX STRENGTH
FSA/HSA Eligible
Sudafed #1 Pharmacist Recommended - Sinus care expert for over 60 years
FOR MAXIMUM STRENGTH RELIEF ASK FOR SUDAFED® AT THE PHARMACY COUNTER
Drug Facts

SUDAFED® Sinus Congestion + Cold Severe Day/Night Tablets

Maximum strength SUDAFED® Sinus Congestion + Cold Severe daytime and nighttime tablets help to relieve nasal congestion, sinus pressure, runny nose, sneezing, headache, body aches, and fever.

Product Details

Get maximum strength relief from sinus congestion and cold symptoms day or night with Sudafed Sinus Congestion + Cold Severe Daytime & Nighttime Tablets. From the #1 decongestant brand*, this combo pack includes daytime cold medicine and nighttime cold and flu medicine for adults.

The daytime nasal decongestant tablets contain pseudoephedrine HCl 30 mg, the strongest ingredient for sinus congestion relief*, plus acetaminophen 500 mg for pain relief and fever reduction. This product starts to work in just 30 minutes to relieve nasal congestion, sinus pressure, body aches, sore throat, and fever.

The nighttime cold medicine tablets contain pseudoephedrine HCl 30 mg, acetaminophen 500 mg, and diphenhydramine HCl 25 mg, an antihistamine that relieves sneezing and runny nose to help you rest. Ask for Sudafed at the pharmacy counter & discover why it’s the best kept secret.

*Among oral OTC decongestants.

SUDAFED® SINUS CONGESTION + COLD SEVERE DAY:

Temporarily relieves these common cold/flu symptoms:

  • minor aches and pains

  • headache

  • sore throat

  • nasal congestion

  • sinus congestion and pressure

  • helps clear nasal passages, promotes nasal and sinus drainage

Temporarily reduces fever

SUDAFED® SINUS CONGESTION + COLD SEVERE NIGHT:

Temporarily relieves these common cold/flu symptoms:

  • minor aches and pains

  • headache

  • sore throat

  • nasal congestion

  • sinus congestion and pressure

  • sneezing and runny nose

  • helps clear nasal passages

Temporarily reduces fever

SUDAFED® SINUS CONGESTION + COLD SEVERE DAY:

Active Ingredients

Purpose

Acetaminophen 500 mg

Pain reliever/fever reducer

Pseudoephedrine HCl 30 mg

Nasal decongestant

Inactive Ingredients
candelilla wax, croscarmellose sodium, crospovidone, FD&C yellow no. 6 aluminum lake, hypromellose, microcrystalline cellulose, polyethylene glycol, povidone, pregelatinized starch, titanium dioxide, zinc stearate

SUDAFED® SINUS CONGESTION + COLD SEVERE NIGHT:

Active Ingredients

Purpose

Acetaminophen 500 mg

Pain reliever/fever reducer

Diphenhydramine HCl 25 mg

Antihistamine

Pseudoephedrine HCl 30 mg

Nasal decongestant

Inactive Ingredients
candelilla wax, croscarmellose sodium, crospovidone, FD&C blue no. 1 aluminum lake, hypromellose, microcrystalline cellulose, polyethylene glycol, povidone, pregelatinized starch, silicon dioxide, titanium dioxide, zinc stearate

Do not take more than directed.

See overdose warning

Age

Dosage

Adults and children 12 years and over

• Take 2 caplets every 6 hours while symptoms last
• Do not take more than 6 caplets in 24 hours, unless directed by a doctor
• Do not use for more than 10 days unless directed by a doctor

Children under 12 years

ask a doctor

Important:
Read all product information before using. Keep this box for important information.
Do not take the day and night tablets at the same time. Do not take more than a total of 6 tablets in a 24-hour period. Take only as directed.

SUDAFED® SINUS CONGESTION + COLD SEVERE DAY:

Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take

  • more than 4,000 mg of acetaminophen in 24 hours.

  • With other drugs containing acetaminophen.

  • 3 or more alcoholic drinks every day while using this product.

Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:

  • skin reddening;

  • blisters;

  • rash.

If a skin reaction occurs, stop use and seek medical help right away.

Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.

Do not use

  • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.

  • If you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

  • If you have ever had an allergic reaction to this product or any of its ingredients.

Ask a doctor before use if you have

  • liver disease or heart disease;

  • high blood pressure,

  • thyroid disease,

  • diabetes;

  • trouble urinating due to an enlarged prostate gland.

Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin.

When using this product do not exceed recommended dose.

Stop use and ask a doctor if

  • nervousness,

  • dizziness, or sleeplessness occur;

  • pain or nasal congestion gets worse or lasts more than 7 days;

  • fever gets worse or lasts more than 3 days;

  • redness or swelling is present,

  • new symptoms occur.

These could be signs of a serious condition.

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

SUDAFED® SINUS CONGESTION + COLD SEVERE NIGHT:

Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take

  • more than 4,000 mg of acetaminophen in 24 hours.

  • With other drugs containing acetaminophen.

  • 3 or more alcoholic drinks every day while using this product.

Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:

  • skin reddening;

  • blisters;

  • rash.

If a skin reaction occurs, stop use and seek medical help right away.

Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.

Do not use

  • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.

  • With any other product containing diphenhydramine, even one used on skin.

  • If you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

  • If you have ever had an allergic reaction to this product or any of its ingredients.

Ask a doctor before use if you have

  • liver disease,

  • heart disease,

  • high blood pressure,

  • thyroid disease,

  • diabetes,

  • trouble urinating due to an enlarged prostate gland,

  • A breathing problem such as emphysema or chronic bronchitis,

  • Glaucoma.

Ask a doctor or pharmacist before use if you are

  • taking the blood thinning drug warfarin.

  • taking sedatives or tranquilizers.

When using this product

  • do not exceed recommended dose.

  • Excitability may occur, especially in children.

  • Marked drowsiness may occur.

  • Alcohol, sedatives and tranquilizers may increase drowsiness.

  • Avoid alcoholic drinks.

  • Be careful when driving a motor vehicle or operating machinery.

Stop use and ask a doctor if

  • nervousness, dizziness, or sleeplessness occur;

  • pain or nasal congestion gets worse or lasts more than 7 days;

  • fever gets worse or lasts more than 3 days;

  • redness or swelling is present,

  • new symptoms occur.

These could be signs of a serious condition.

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

  • Store between 20 - 25°C (68 - 77°F)

  • Do not use if blister unit is torn or broken

 #1 pharmacist recommended decongestant brand

#1 Pharmacist Recommended Decongestant Brand*

*IQVIA ProVoice Survey, 12 Months Ending September 2025

Reviews

Sudafed Logo
Products
  • All Products
  • Compare SUDAFED®
  • Where To Buy
Company
  • Contact Us
  • Coupons & Offers
Learn
  • All Articles
  • Dosing Guide
  • Medicine Disposal
  • FAQs
Legal
  • Legal Notice
  • Privacy Notice
  • Do Not Sell or Share My Personal Information
  • Limit the Use of My Sensitive Personal Information
  • Consumer Health Data Privacy Notice
  • AdChoices

​© Kenvue Brands LLC. 2026. All rights reserved. This site is published by Kenvue Brands LLC, which is solely responsible for its contents. This website is intended for visitors from the United States. The third-party trademarks used herein are trademarks of their respective owners.